bookcurios Chapter 450 Terminology
Chapter 450 Terminology
Chapter 450 Terminology
Li Ang glanced at the Asgardian Heavenly Father contained in the glass jar, and said calmly, "As I said before, there are two explanations for the reason why life forms 'age and die'.
One is that the living body automatically evolves a death mechanism, and the other is that the living body suffers wear and tear during its operation.
Regarding the first theory, the Academy City Regenerative Medicine Department under the leadership of Dr. Strange believes that the purpose of delaying the limit of physiological life can be achieved by artificially intervening in the aging process. "
After all, he raised his hands, a healthy spindle cell projection was suspended above his left hand, and a bloated spindle cell projection was suspended above his right hand.
"The ones on the left are normal cells, and the ones on the right are senescent cells."
Li Ang held up two phantoms, and asked Thor and the others: "Do you see any difference?"
Thor scratched his forehead, and it was okay to go into battle with a hammer to kill the enemy. It was really difficult for the God of Thunder to identify the cell map.
On the contrary, Luo Ji slightly raised her hand and said, "There are more damaged DNA in aging cells."
"Yes."
Li Ang nodded and said: "According to common sense, the senescent cells in multicellular organisms, especially the human body, will be replaced by new cells, but as time goes by, the senescent cells will start to occupy the latrine and be retained. , promotes the aging of multicellular organisms.
This abnormality is due to the shutdown of the p53 protein in the human body.
P53基因是一种抑癌基因，定位于人类染色体17p13.1，编码393个氨基酸组成的53kD的核内磷酸化蛋白，被称为p53蛋白。
It is responsible for cell cycle regulation, DNA repair, cell differentiation, and apoptosis.
Once the p53 protein is shut down, the senescent cells cannot be directed to die, and eventually become crowded inside the body, accelerating the aging process of the body. "
Speaking of this, Li Ang glanced at the Odin family, and found that only Luo Ji and Queen Freya could understand, while Thor and Odin were in a state of bewilderment.
The queen Freya can understand it because she is quite studious. After selling herself in Academy City, she knows her shame and is brave, absorbing knowledge like a sponge.
And Luo Ji could understand it, all because she was injured too deeply in the last "Frost Giant Sex Chromosomal Disorder Incident".
For this god of lies and cunning, it was hard for her to bear the feeling of being completely ignorant and completely out of her control.
Therefore, in addition to being an idol, Rocky also made up for a while in genetic biology.
From this point of view, she is many times stronger than some Thor who only likes to think with muscles.
Li Ang smiled, and said persuasively: "On this basis, Doctor Strange has done further research.
They found that a transcription factor called FOXO4 binds to p53 and prevents p53 from doing its job and causing the senescent cells to die.
This FOXO4 transcription factor is quite domineering, and can force p53 to have a relationship with it. The solution is to inject a FOXO4 substitute, FOXO4-DRI short peptide.
This short peptide is a D-retro inverso isoform, which simply means that the L-type amino acid is replaced by a D-type, and the direction of the backbone is also reversed.
FOXO4-DRI short peptide has a higher priority than FOXO4, and is more domineering than the domineering president. It can deprive FOXO4 of the 'mating right' and preferentially bind to P53 without preventing the latter from continuing to function.
Macroscopically, the short peptide can target aging cells to undergo apoptosis, thereby promoting new cells to replace old cells, thereby delaying or even preventing the overall aging process of an individual's life. "
It has to be said that Freya, the Queen of Heaven, has a quick mind, and she has already guessed Li Ang's intentions after such a short effort, and said a little excitedly: "Then if this kind of FOXO4-DRI is injected into Odin's body, he is already on the verge of The aging and collapsing divine body starts to metabolize again, destroying old cells and producing new ones,
My husband doesn't have to die? ! "
As soon as these words came out, not only Thor's face flashed with excitement, but even Odin in the glass cylinder showed a little emotional fluctuation.
He just saw through the essence of some things and looked down on the world, not that he wanted to die.
If the life span can be extended by another hour, one minute, or even one month, one year, who would want to die?
Unexpectedly, Li Ang shook his head, and poured cold water on the excited Freya and the others, "It's not that simple.
FOXO4——DRI short peptide is just an experimental product. Even though Aotron joined in later, the computing power of the entire scientific research project has been qualitatively improved.
However, several transcription factors with similar effects to the short peptide have been proposed.
Odin's divine body has long been on the verge of limit, similar to the realm of the five decays of heaven and man, every part of his body began to decay and decay.
All these transcription factors are tied together to make the 'aging cell targeting apoptosis agent'. If it is directly injected into Odin's body, it will only cause the cells in his whole body to collapse instantly, turning him into a pool of unconscious cells Soup. "
Freya and the others froze in an instant. The gap between hope and disappointment was too great.
This is actually the reason for Odin himself. If he is not the God King of the Asa Protoss, but just an ordinary old man on the earth, he can completely rely on the primitive cells in the underground base of Academy City to solve the problem.
Protocells, which have long been able to proliferate indefinitely, can invade the host's body, attack the city between the cells and tissues, replace most of the host's body, and allow the host to achieve another degree of immortality.
However, the powerful divine body of the Asa Protoss can block the erosion of the primitive cells, preventing the latter from helping the former to extend their lifespan.You must rely on the life mechanism in your own body to resist aging.
Just when Freya and the others were disappointed, Li Ang said slowly: "In the first explanation of the death of living organisms, the senescent cell-targeted apoptosis agent containing FOXO4-DRI short peptide can indeed play a part. effect.
However, the apoptosis-targeting agent is like a double-edged sword, it will break the dynamic balance of cells in Odin's body.
At this time, we can turn our attention to the second explanation of the death of living organisms. "
The second explanation?
Luo Ji and Freya quickly cheered up. According to their little understanding of Li Ang, this second explanation is the highlight.
Sure enough, Li Ang said slowly: "The second explanation for the death of living bodies is the 'principle of wear and tear'.
The free radicals produced during mitochondrial metabolism can damage DNA, causing abnormal and damaged cells to gradually accumulate, forming aging.
This is almost an unavoidable thing. The thermal movement and regular metabolism in the human body will inevitably lead to the gradual breaking of the chemical bonds in the protein.
It is this kind of chemical bond breakage that accumulates more and more, so that there are more necrotic cells and the human body gradually ages.
To use a more professional term, it is 'the gradual decrease of molecular fidelity and the gradual increase of molecular disorder have produced changes in molecular structure, resulting in changes in the overall function of cells and ultimately aging'. "
(End of this chapter)